Somnolence was the most commonly observed adverse reaction in the clinical trial of bipolar disorder in children and adolescents, as well as in the schizophrenia trials in adolescents. As was seen in the autistic disorder trials, these adverse reactions were most often of early onset and recovery is possible for everyone transient in duration [see ADVERSE REACTIONS]. Patients experiencing persistent somnolence may benefit from a change in dosing regimen [see DOSAGE AND ADMINISTRATION]. Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death.
Risperidone side effects
Babies born to mothers who have used this drug during the last 3 months of pregnancy may rarely develop symptoms including muscle stiffness or shakiness, drowsiness, feeding/breathing difficulties, or constant crying. If you notice any of these symptoms in your newborn especially during their first month, tell the doctor right away. You may report side effects to FDA at FDA-1088 or at /medwatch. This medication may increase a certain natural substance (prolactin) made by your body. For females, this increase in prolactin may result in unwanted breast milk, missed/stopped periods, or difficulty becoming pregnant. For males, it may result in decreased sexual ability, inability to produce sperm, or enlarged breasts.
What should I know about storage and disposal of this medication?
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. This medicine may increase prolactin blood levels if used for a long time. Visit your care team for regular checks on your progress. Tell your care team if symptoms do not start to get better or if they get worse.
Dosage for Risperdal
- Risperidone may increase the risk of death in older adults with dementia-related psychosis and is not approved for this use.
- A dose reduction should be considered if hypotension occurs.
- Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status including delirium, and autonomic instability (irregular pulse or blood pressure, tachycardia, diaphoresis, and cardiac dysrhythmia).
- This includes prescription and over-the-counter medicines, vitamins, and herbal products.
- The long-term effects of RISPERDAL® on growth and sexual maturation have not been fully evaluated in children and adolescents.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. Note that this list is not all-inclusive and includes only common medications that may interact with Risperdal. You should refer to the prescribing information for Risperdal for a complete list of interactions.
Alternative treatments
Risperidone is a type of antipsychotic medication that treats mental health conditions schizophrenia, bipolar disorder and some symptoms of autism. Risperidone can cause metabolic changes that might increase your risk for having a stroke or heart attack. You and your doctor should watch your blood sugar, symptoms of diabetes (weakness or increased urination, thirst, or hunger), weight, and cholesterol levels. It comes as an oral tablet, an orally disintegrating tablet, and an oral solution.
Remove an orally disintegrating tablet from the package only when you are ready to take the medicine. Place the tablet in your mouth and allow it to dissolve, without chewing. Risperidone is also used to treat symptoms of bipolar disorder (manic depression) in adults and children who are at least 10 years old. Although there are no mandatory requirements for therapeutic drug monitoring (TDM) with risperidone, monitoring plasma concentrations for this medication is strongly recommended by European guidelines because of data showing interdependent variability.
Manifestations can include confusion, obtundation, postural instability with frequent falls, extrapyramidal symptoms, and clinical features consistent with neuroleptic malignant syndrome. In patients with moderate to severe (Clcr 59 to 15 mL/min) renal disease, clearance of the sum of risperidone and its active metabolite decreased by 60%, compared to young healthy subjects. RISPERDAL® doses should be reduced in patients with renal disease [see DOSAGE AND ADMINISTRATION].
A class of drugs is a group of medications that work in a similar way. Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/”water pills”) or if you have conditions such as severe sweating, diarrhea, or vomiting. There may be a slightly increased risk of serious, possibly fatal side effects (such as stroke, heart failure, fast/irregular heartbeat, pneumonia) when this medication is used by older adults with dementia.
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It is an atypical antipsychotic, which means it can treat psychosis, the main symptom of schizophrenia. On rare occasions, exposure to atypical antipsychotics can result in a potentially life-threatening reaction. If you are on this drug for an extended period, your risk of EPS may also increase.
These side effects affect the central nervous system and cause movement problems. RxList does not provide medical advice, diagnosis or treatment. In plasma, risperidone is bound to albumin and α1-acid glycoprotein. The plasma protein binding of risperidone is approximately 90%, and that of its major metabolite, 9-hydroxyrisperidone, is 77%. Neither risperidone nor 9-hydroxyrisperidone displaces each other from plasma binding sites.
When treating pediatric patients with RISPERDAL® for any indication, weight gain should be assessed against that expected with normal growth. Weight gain has been observed with atypical antipsychotic use. RISPERDAL® (risperidone) is not approved for the treatment of dementia-related psychosis [see BOX drunk people feel soberer around heavy drinkers WARNING]. RISPERDAL® M-TAB® (risperidone) Orally Disintegrating Tablets are etched on one side with “R0.5”, “R1”, “R2”, “R3”, or “R4” according to their respective strengths. RISPERDAL® MTAB® Orally Disintegrating Tablets 0.5 mg, 1 mg, and 2 mg are packaged in blister packs of 4 (2 X 2) tablets.
Use Risperal Consta exactly as prescribed by your doctor. If you already use other antipsychotic medication, you may need to keep using it for a short time. Do not change your dose or dosing schedule without your doctor’s advice. If you have questions about side effects, call your doctor. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use risperidone only for the indication prescribed. Drinking alcohol can increase certain side effects of this medicine.
Data from clinical trials collected over a period of 10 weeks showed a 4.5 percent rate of death in patients treated with atypical antipsychotic drugs compared with a 2.6 percent risk in patients treated with a placebo. While causes of those deaths varied, the majority were cardiovascular deaths, heart failure or sudden death, or infectious conditions such as pneumonia. RISPERDAL® has been shown to elevate prolactin levels in children and adolescents as well as in adults [see WARNINGS AND PRECAUTIONS].
Patients experiencing persistent somnolence may benefit from a once-daily dose administered at bedtime or administering half the daily dose twice daily, or a reduction of the dose. Although there are no data to specifically address reinitiation of treatment, it is recommended that after an interval off RISPERDAL®, the initial titration schedule should be followed. Patients experiencing persistent somnolence may benefit from administering half the daily dose twice daily. This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.
It also comes as an injection that’s only given by a healthcare provider. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Data sources include Micromedex (updated 4 Jun 2024), Cerner Multum™ (updated 3 Jun 2024), ASHP (updated 10 Jun 2024) and others. If NMS occurs, symptoms generally appear within two weeks of starting the drug. Factors that appear to increase the risk of NMS include exhaustion, dehydration, and malnutrition, with young adult males and people who have organic brain syndromes or intellectual disabilities being affected most often.
